Haworth, Brian T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a facilitated problem-based learning (PBL) format. Methods Three methods were used to compare in-class versus online discussion sessions for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student’s perceptions of the discussions with surveys. The third method mapped the interactions (a sociogram) between faculty (facilitator) and students in a discussion. Results There were significantly lower scores for Par and St–St (P < 0.05)>
Physiological aim and you may pharmacology of curcumin
Book ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca M. Romero, Ian S Haworth Curcumin is the big element of the purple color from turmeric, a keen Indian spruce which is taken from the latest rhizome of one’s warm bush Curcuma longa, hence is one of the Zingiberaceae nearest and dearest. Inside chapter, i talk about the pharmacological products from curcumin and you may talk about the fresh new unit angles of these products. We following feedback the new shown and you will prospective medical spends off curcumin. Curcumin is known usually given that a curative agent, however, their method out-of step try outlined. The fresh new pharmacological results of curcumin be seemingly the consequence of an effective synergism from companies regarding poor biochemical connections that have multiple physical targets during the interrelated signaling paths. These types of purpose become enzymes like cyclooxygenase, lipoxygenase and you can healthy protein kinases, and transcription affairs including NF-?B, STAT and Nrf2. Modulation of those particles has an effect on downstream affectors which make brand new antiinflammatory, antioxidant, chemopreventive, anticancer, and antimicrobial situations out of curcumin. Such effects was basically tested in scientific examples off curcumin to possess aches and inflammatory diseases, cancer tumors, Alzheimer problem, cardio sickness, and diabetes. The new samples have used adjustable amounts out-of curcuminwith more wavelengths and stage, on general conclusion one to large dosages from curcumin on quantity of g have to get therapeutic consequences. Read more
Curcumin: Synthesis, Growing Character in the Pain Administration and you can Fitness Implications
Guide Part Types of plant-derived pharmaceuticals that have get to be the attract off proceeded tjek indlægget lige her and you can exponential browse and you can development desire has, so far, become slightly scarce. Just after many years, the very last two decades have been characterized by a 100-bend rise in what amount of medical stuff wrote a-year you to definitely try regarding importance on accessibility curcumin inside biomedicine. Read more
Framework, synthesis and physiological factors from curcumin prodrugs
Book ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Meters. Romero, Ian S Haworth Curcumin has many prospective pharmacological effects and may even enjoys healing apps in many condition claims, as discussed in more detail in the last part. Yet not, the potential health-related effectiveness out of curcumin is restricted of the its physicochemical characteristics out of poor water solubility and you can instability, and that end in lower bioavailability. Prodrugs regarding curcumin render an easy way to upgrade of one’s biopharmaceutical and you will pharmacokinetic services, and can even enable it to be exploitation of your own pharmacological effects of curcumin. Contained in this chapter, we earliest review the new physicochemical and you may pharmacokinetics from curcumin. I following determine the style of curcumin prodrugs that have increased water solubility and you may improved chemical substances balance which is often translated back to free curcumin upon bioactivation inside the vivo. I focus on previous profits of this type, that have a concentrate on the build, synthesis and evaluation out of prodrugs according to promoieties plus amino acids, efas, nucleic acids, dicarboxylic acids, and you can polymeric content like hyaluronic acidic and you will polyethylene glycol. So it part gets the reason for optimization of your physicochemical and you may biopharmaceutical services plus the biological affairs out of curcumin prodrugs, towards the objective using of these curcumin derivatives inside systematic apps. Find out more
