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- In addition, the info out there within the literature does not account for the steroid type or dose, as neither could additionally be known.
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Unfortunately, the info on the use of excessive dose anabolic steroids in humans are primarily offered as case stories or small research that lack enough management groups. In addition, the information available in the literature doesn’t account for the steroid sort or dose, as neither could additionally be recognized. Patients additionally may be taking concomitant stimulants, corresponding to ephedra, which may confound data and the potential for adverse occasions. It is likely that the frequency of cardiac occasions is underreported within the medical literature. Supraphysiologic doses of anabolic-androgenic steroids , which embrace greater than 30 natural and synthetic derivatives of testosterone, may cause a large spectrum of scientific sequalae.
We report a case of an acute ST-segment elevation myocardial infarction in a patient with traditional cardiac threat elements using supraphysiologic doses of supplemental, intramuscular testosterone. In addition, this patient additionally had polycythemia, doubtless secondary to high-dose testosterone. The patient underwent successful percutaneous intervention of the proper coronary artery. Physicians and patients ought to concentrate on the clinical consequences of anabolic steroid abuse.
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Development of an atheromatous plaque perpetuates endothelial dysfunction and promotes platelet aggregation and intracoronary thrombus formation (Ajayi et al 1995; Nieminen et al 1996). Moreover, a part of endothelial dysfunction has been proposed, which can contribute to irregular vessel reactivity. However, testosterone in physiologic doses could even be useful in patients with angina , have larger ischemic thresholds and improved quality of life . Short-term intracoronary administration of testosterone induces coronary artery dilation and will increase coronary blood move in men with established coronary artery disease .
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